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O-38 - In 1,876 angiography patients, plasma choline-TMAO-betaine show dose-dependent association with prevalent CVD and TMAO tracks coronary burden

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Properties7
type
observation
id
O-38
statement
In an independent cohort of 1,876 stable patients undergoing elective cardiac evaluation, elevated plasma choline, TMAO, and betaine showed dose-dependent associations with the presence of cardiovascular disease that held after adjustment for traditional risk factors, and plasma TMAO correlated with angiographic coronary atherosclerotic burden.
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linked
source
S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)
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Fig 3a-c,f; Results (confirmation cohort)
data_basis

Human observational finding on the GeneBank/BioBank angiography population (D-4). Cross-sectional/prevalent-CVD association in a sick, referral-selected cohort — confounding and reverse causation not excluded.

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added after the FLF submission deadline

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