Registered RCT (ACTRN12612001266853); the tight CI straddling zero on a pre-specified primary endpoint is the study’s headline null.
Methodology
Registered RCT (ACTRN12612001266853): 140 overweight/obese adults with prediabetes or type 2 diabetes randomised to a high-egg diet (2 eggs/day, 6 days/week; ~12 eggs/week) or a low-egg diet (<2 eggs/week) for 3 months, embedded in a weight-maintenance program. Both arms received matched macronutrient advice, with a counselled increase in MUFA/PUFA, so the background diet was equalised across arms (a design choice that can blunt a true egg effect). Unblinded, single-site/single-team (Boden Institute, Sydney). Primary outcome: change in HDL-C from screening to 3 months; secondaries: total cholesterol, LDL-C, triglycerides, glycemic control, and appetite ratings. Funding: Australian Egg Corporation (egg-industry funder — a conflict of interest not captured in the step-1 motivatedness note). Depth-limited: exact per-arm secondary values were not recoverable from the accessible abstract/text.
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