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O-63 - Free choline (choline bitartrate) raised fasting TMAO ~6-fold and increased platelet reactivity

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type
observation
id
O-63
statement
Choline bitartrate tablets (~411 mg free choline/day) raised fasting plasma TMAO roughly 6-fold (1.9 -> 11.1 uM, P<0.0001) and significantly increased 24-hour urinary TMAO (P<0.001) and platelet responsiveness (P<0.01); the effect held across all three choline-tablet-containing arms.
link_state
linked
source
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator
Results, choline-bitartrate arms (Arms 2-4); positive control
quote
1.9 [1.4-3.4] vs. End 11.1 [7.1-25.4] uM; P<0.0001

The validated far-from-threshold positive control that anchors the trial: free choline at a dose comparable to the eggs’ choline content produced a large TMAO and platelet-reactivity response.

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