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O-67 - Adding egg whites to choline-bitartrate did not suppress the choline-driven TMAO rise

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Properties6
type
observation
id
O-67
statement
The arm giving egg whites plus choline-bitartrate tablets (n=18) still showed a large fasting TMAO rise (to 28.1 uM, P<0.0001); egg-white antimicrobial peptides had no significant suppressive effect on choline/phosphatidylcholine-dependent TMAO.
link_state
linked
source
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator
Results, egg-white + choline arm (Arm 4); antimicrobial-peptide test

A designed mechanism-dissection arm: it rules out egg-white antimicrobial peptides (e.g., ovodefensins) as the explanation for the whole-egg TMAO null.

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