EpiStack

O-71 - Serum beta-carotene shows a strong protective mortality association in cohorts (RR 0.69) that randomized trials exclude

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Properties9
type
observation
id
O-71
statement
Meta-analyzed cohort data give a relative risk of death of 0.69 (95% CI 0.59–0.80) for the highest vs lowest serum/plasma beta-carotene — a strong protective association measured with an objective biochemical assay — yet multiple large randomized trials have excluded even a small mortality benefit (and beta-carotene supplementation showed harm).
link_state
linked
source
S-95 - The case that nutritional-epidemiology cohort methods need radical reform
locator
Viewpoint, paragraph on single-nutrient studies vs trials (ref. Zhao 2016)
quote
The relative risk of death for the highest vs lowest group of beta carotene levels in serum or plasma was 0.69 (95% CI, 0.59-0.80).
generally_known
true
data_basis
—

A referenced fact resting on no data of the Viewpoint’s own. Discriminating value: even when dietary measurement error is bypassed with a biochemical assay, the cohort association failed to replicate in randomized trials — evidence that the confounding/selection problem, not just measurement error, drives nutritional-cohort associations.

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