EpiStack

O-75 - Fasting total cholesterol rose 1.47 mg-dL per 100 mg dietary cholesterol across a 0-4 egg-day crossover (linear, no threshold)

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Properties7
type
observation
id
O-75
statement
In 20 healthy young men in an 8-week four-way randomized crossover feeding 0, 1, 2, or 4 eggs/day (128-858 mg dietary cholesterol/day), fasting plasma total cholesterol increased by 1.47 mg/dL (0.038 mmol/L) for every 100 mg dietary cholesterol added, linearly across the full range with no apparent threshold (P<0.001).
link_state
linked
source
S-42 - Ginsberg 1994 Arterioscler Thromb — dose-response of dietary cholesterol-egg feeding on lipoproteins in healthy young men
locator
Abstract; Results
quote
Fasting plasma total cholesterol concentrations increased by 1.47 mg/dL (0.038 mmol/L) for every 100 mg dietary cholesterol added to the diet (P < .001).

Corrected/true design (per step-2a note): a 20-man 8-week crossover of 0/1/2/4 eggs (128-858 mg/d), not the ‘0/750/1500 mg P:S-ratio’ design in the original node summary.

Methodology

Controlled-feeding dose-response study: 20 healthy young men in a randomized four-way crossover, each eating 0, 1, 2, or 4 eggs/day (total dietary cholesterol 128 to 858 mg/day) for 8 weeks per diet, with a break between diets. Fasting and postprandial (postlunch and post-fat-formula) plasma lipids, lipoproteins, and apolipoproteins were measured. NIH/Columbia academic trial. Full text was paywalled (AHA journals 403); extraction rests on the verbatim PubMed/Europe PMC abstract (which carries the key slopes).

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