Fully-adjusted (stratified Cox on survey site + birth cohort; attained age as timescale; adjusted for age, sex, education, income, marital status, alcohol, smoking, physical activity, BMI, waist-hip ratio, hypertension, aspirin, family CVD history, multivitamins, dietary pattern). Category HRs (95% CI) vs never/rarely: 1-3 days/month 0.97 (0.95-1.00); 1-3 days/week 0.92 (0.90-0.94); 4-6 days/week 0.90 (0.87-0.93); daily 0.89 (0.87-0.92). Per +1 egg/week: 0.97 (0.96-0.98).
Methodology
Prospective cohort of 512,891 adults aged 30-79 from 10 regions (5 urban, 5 rural) of China, recruited 2004-2008; 461,213 eligible after excluding prior cancer/heart disease/stroke/diabetes and missing BMI. Median follow-up 8.9 y (3.9M person-years to 31 Dec 2015). Egg intake by a laptop-based single-baseline qualitative FFQ (categories never/rarely, 1-3 days/month, 1-3 days/week, 4-6 days/week, daily) covering the prior 12 months; usual amounts calibrated from a 2013-14 resurvey. Outcomes (CVD I00-I99, IHD I20-I25, haemorrhagic stroke I61, ischaemic stroke I63, major coronary events = fatal IHD or non-fatal MI) ascertained via disease/death registries, national health-insurance linkage, and active follow-up. Stratified Cox models (strata: survey site, 5-year birth cohort; attained age as timescale); fully-adjusted Model 3 covariates: age, sex, education, household income, marital status, alcohol, smoking, physical activity, BMI, waist-hip ratio, prevalent hypertension, aspirin use, family CVD history, multivitamin use, dietary pattern. Linear trend by category midpoints. Prespecified stratified analyses by sex, age, area, education, income, alcohol, smoking, physical activity, dietary pattern, BMI, hypertension.
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