EpiStack

O-34 - Gut flora are obligately required to convert dietary phosphatidylcholine-choline to TMAO in mice (germ-free and antibiotic abolition, conventionalization restores)

1 min read

Properties7
type
observation
id
O-34
statement
In mice, germ-free status and 3-week broad-spectrum antibiotic pretreatment completely abolished appearance of d9-TMAO after oral d9-phosphatidylcholine or d9-choline; re-colonizing antibiotic-treated mice with normal flora ('conventionalization') restored d9-TMAO production.
link_state
orphan
source
S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)
locator
Fig 2c; Suppl Fig 7b,c
data_basis

Own isotope-tracer experiment establishing that intestinal microbiota are necessary for TMA/TMAO generation from dietary PC/choline.

Graph View

Show model graphinteractive Bayesian view — separate from the graph above
added after the FLF submission deadline

Backlinks