O-9 - Egg intake modestly inversely associated with IHD in EPIC, HR 0.93 per 20 g per day

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Why this is evidence

Per-member (H-2, H-3, H-4, H-9, H-10, H-12):

  1. H-2: predicted, though the effect is small.
  2. H-3: mildly disconfirmed (wrong sign, though on a CVD not mortality endpoint).
  3. H-4: predicts a null on IHD but explicitly expects a weak apparent inverse from reverse causation - so it accommodates HR 0.93 well.
  4. H-9: predicted (large healthy Western cohort, no increased risk).
  5. H-10: predicted at the ‘no material effect’ level - 0.93 per 20 g/d is small.
  6. H-12: compatible, unexplanatory.