O-21 - A higher-intake-lower-MI signal appeared in PURE alone but was not replicated in ONTARGET-TRANSCEND
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Why this is evidence
Per-member (H-2, H-3, H-4, H-9, H-10, H-12):
- H-2: disconfirmed - the one protective signal in PURE fails external replication, so protective findings elsewhere (e.g. CKB) look more like population-specific noise.
- H-3: unengaged (no harm shown either).
- H-4: mildly predicted (apparent inverse signals are artefactual).
- H-9: predicted.
- H-10: predicted - non-replication is what a true global null generates.
- H-12: mildly disconfirmed - a real direction-varying effect would more often replicate within a matched patient population.