summary - Randomized 4-way crossover in 20 healthy young men eating an AHA Step 1 background diet supplemented with 0, 1, 2, or 4 egg yolks/day. Fasting and postprandial LDL-C and total cholesterol rose with dietary cholesterol dose, but the response flattened at higher intakes - consistent with partial homeostatic compensation (down-regulated endogenous synthesis/absorption) rather than a linear dose-response.
relevance_note - The modern reference controlled-feeding dose-response study for egg/dietary-cholesterol to LDL-C; the direct 1990s successor to the Keys tradition, in a fully within-subject crossover design.