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S-17 - Intake of up to 3 eggs per day is associated with changes in HDL function and increased plasma antioxidants in healthy young adults

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Properties23
type
source
id
S-17
source_type
journal-article
url
https://www.sciencedirect.com/science/article/pii/S0022316622106760
venue
The Journal of Nutrition
publication_date
2017
citation_count
unknown
citation_count_asof
2026-07-20
field
nutritional science
authors
  • Deanna M. DiMarco
  • Gregory H. Norris
  • Courtney L. Millar
  • Christopher N. Blesso
  • Maria Luz Fernandez
found_via
snowball from Fernandez-lab whole-egg RCT line named in slice brief
motivatedness
Fernandez/DiMarco lab; a companion paper from the same trial line (DiMarco et al. 2017, Lipids, on HDL-C/choline/TMAO) discloses Egg Nutrition Center funding - not individually re-confirmed for this exact paper
trust_score
0.6
trust_reason
Within-subject dose design but small N=38, industry-linked funding, and many measured endpoints; some effects near-mechanical (carotenoids), others (HDL function/particle) softer, capping replication confidence.
usefulness
3
usefulness_reason
Reframes egg effect from LDL-C mass to particle size/function, moderately surprising and discriminating for the surrogate-mismeasurement hypothesis, but small-n surrogate endpoints.
method_read
Dose-ranging feeding trial (N=38, 0-3 eggs/day) on mechanistic endpoints: larger LDL/HDL particles, HDL PON1 function, plasma lutein/zeaxanthin up, standard LDL-C/ApoB unchanged; small N, young-healthy sample, multiple-comparison risk.
standing
J Nutr; Fernandez/DiMarco lab, Egg Nutrition Center-linked funding; mechanistic claims have limited independent replication (carotenoid rise robust, particle/function softer).
angle
feeding-rct-mechanism
data_basis
combined_score
0.15
curated
false
curation_reason
Below top-10 (0.15); mechanism angle now represented by S-19.

summary - Dose-ranging trial in 38 healthy young adults consuming 0-3 eggs/day. Egg intake increased large (more buoyant, less atherogenic) LDL and HDL particle concentrations, HDL antioxidant (PON1) function, and plasma lutein/zeaxanthin, with no adverse change reported in the standard LDL-C/ApoB panel; benefits were dose-dependent up to 3 eggs/day.

relevance_note - Shifts the outcome from LDL-C mass to particle size/function - the mechanistic case that standard LDL-C may mismeasure egg’s cardiovascular effect.

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