Screened 88,517 archived plasma samples from 76,844 Wuhan blood donors, Sept 1-Dec 31 2019 (43,850 samples from 32,484 donors with adequate volume/quality tested). 264 samples from 213 donors were reactive on a pan-immunoglobulin screening assay (some also IgG- or IgM-reactive), an initially eyebrow-raising signal later cited by lab-leak proponents as possible evidence of pre-outbreak circulation. However, confirmatory microneutralization testing of all reactive samples was negative, and the authors conclude there is no serological evidence of SARS-CoV-2 circulation among Wuhan blood donors before December 2019. relevance_note: the key primary data behind the disputed “early Wuhan antibodies” claim — records the actual reactive/non-reactive counts and the neutralization-negative resolution, so later steps can weigh the raw signal against the authors’ negative interpretation rather than taking either side’s summary on faith.