O-86 - In PURE one or more eggs per day not associated with composite CVD-mortality, total mortality, or major CVD
Cox frailty model with center random intercepts (adjusts region/country); covariates age, sex, education, urban/rural, smoking, physical activity, diabetes history, intakes of fruit/vegetables/red meat/poultry/fish/dairy, % energy from carbohydrate, total energy. Dose-response (per +0.5 egg/day) and cubic-spline analyses also null (P-trend >0.10). Further adjustment for blood cholesterol did not change results.
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Why this is evidence
PURE is a 50-country cohort that includes Asian and Chinese participants and adjusts for region (center random intercepts), yet finds a null egg-CVD association explicitly consistent across geographic regions. H-22 predicts an inverse Asian signal should re-appear; H-7 and H-50 predict the Kadoorie inverse should NOT reproduce in a better-controlled, region-adjusted multi-region cohort.