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EpiStack v1 — FLF competition

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H 37 Moderate habitual egg intake up to one per day is neutral for CVD and mortality across income levels globally

H-37 - Moderate habitual egg intake up to one per day is neutral for CVD and mortality across income levels globally

Jul 23, 20261 min read

Properties8

type: hypothesis
id: H-37
state: merged
question: Is moderate habitual egg consumption net beneficial, harmful, or neutral for CVD and mortality?
statement: Habitual egg consumption at moderate levels (up to ~1 egg/day) neither increases nor decreases cardiovascular disease or mortality risk, and this neutrality holds across low-, middle- and high-income countries and diverse diets.
merged_into: H-21 - Moderate egg intake has no causal effect on CVD risk overall
source: S-91 - PURE study- egg intake, blood lipids, CVD and mortality in 50 countries (Dehghan 2020)
locator: Discussion / Conclusion

The authors’ headline reading of concordant null associations in PURE and ONTARGET/TRANSCEND across 50 countries and all income levels.

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added after the FLF submission deadline

Backlinks

A-30 - High event count makes PURE's tight null informative against a moderate harm or benefit of eggs
A-31 - Absence of any adverse lipid change removes the main a-priori pathway for egg harm, making the null mechanistically coherent
A-32 - Isolated MI and prevalent-CVD-subgroup signals are best read as chance given multiplicity and non-replication
H-21 - Moderate egg intake has no causal effect on CVD risk overall
S-91 - PURE study- egg intake, blood lipids, CVD and mortality in 50 countries (Dehghan 2020)

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