EpiStack

O-21 - Early egg introduction raised hospital admissions (10% vs 0%) though acute-reaction rates were similar between arms (PETIT)

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Properties7
type
observation
id
O-21
statement
In the PETIT RCT, hospital admissions occurred in 6/60 (10%) of the egg-introduction group versus 0/61 in placebo (p=0.022); acute allergic events after trial-powder intake occurred in 9 (15%) egg-group versus 11 (18%) placebo-group participants (19 vs 14 events).
link_state
linked
source
S-15 - Natsume 2017 - PETIT trial- two-step egg introduction prevents egg allergy in high-risk infants
locator
Findings, adverse events
quote
The only difference in adverse events between groups was admissions to hospital (six [10%] of 60 in the egg group vs none in the placebo group; p=0.022)

Safety signal: the intervention was not free of acute allergic reactions — hospital admissions (for reactions to the egg powder) were significantly higher in the egg arm, even though the overall count of participants with acute events after powder intake was slightly lower in the egg arm than placebo.

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