EpiStack

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EpiStack v1 — FLF competition

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observations and facts

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O 33 Choline, TMAO and betaine upregulate macrophage scavenger receptors CD36 SR A and promote foam cell formation in mice

O-33 - Choline, TMAO and betaine upregulate macrophage scavenger receptors CD36-SR-A and promote foam-cell formation in mice

Jul 23, 20261 min read

Properties7

type: observation
id: O-33
statement: Dietary supplementation with choline, TMAO, or betaine (>3 weeks) increased surface CD36 and SR-A1 scavenger-receptor levels on mouse peritoneal macrophages and markedly enhanced macrophage cholesterol accumulation / foam-cell formation relative to control chow.
link_state: linked
source: S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)
locator: Fig 4f,g; Fig 5a-c; Suppl Fig 20
data_basis: S-28

Own mouse/macrophage experiment establishing the proposed atherogenic mechanism (scavenger-receptor-driven foam-cell formation).

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added after the FLF submission deadline

Backlinks

A-11 - Germ-free-antibiotic necessity plus TMAO-supplementation sufficiency plus host-genetic segregation jointly establish a causal choline--flora--TMAO--atherosclerosis chain in mice
E-67 - O-33 x HC-8 — TMAO drives macrophage foam-cell formation
S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)

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