EpiStack

O-37 - Plasma choline, TMAO and betaine predict 3-year incident MI, stroke or death in a prospective angiography sub-cohort

1 min read

Properties7
type
observation
id
O-37
statement
In a prospective GeneBank sub-cohort of stable patients undergoing elective coronary evaluation, plasma choline, TMAO, and betaine (identified by untargeted metabolomics) were associated with 3-year incident risk of myocardial infarction, stroke, or death (learning cohort 50 cases vs 50 matched controls; validation cohort 25 vs 25).
link_state
linked
source
S-28 - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease (Wang et al. 2011, Nature)
locator
Fig 1; Results (metabolomics discovery)
data_basis

Human observational finding, resting on the Cleveland Clinic GeneBank angiography cohort (D-4). Prospective incident-event design partly mitigates reverse causation, but n is small and the population is referral-selected.

Graph View

Show model graphinteractive Bayesian view — separate from the graph above
added after the FLF submission deadline

Backlinks