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O-66 - Platelet responsiveness correlated with TMAO levels across participants

Jul 23, 20261 min read

Properties6

type: observation
id: O-66
statement: Across participants, platelet responsiveness was strongly correlated with TMAO in both fasting plasma (r=0.51, P<0.0001, N=49) and 24-hour urine (r=0.53, P<0.0001, N=49).
link_state: linked
source: S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)
locator: Results, platelet-TMAO correlation

Links the TMAO differences to a functional prothrombotic readout: participants with higher TMAO had higher platelet reactivity, regardless of arm.

added after the FLF submission deadline

E-73 - O-66 x HC-8 — platelet reactivity correlates with TMAO in humans
S-60 - Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function- a randomized clinical trial (Wilcox et al. 2021, Am J Med)