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O-82 - LDL-C response to saturated fat was slightly larger in APOE E3-4 or E4-4 carriers than E3-3

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Properties7
type
observation
id
O-82
statement
The LDL-C response to saturated fat was 0.08 mmol/L larger in APOE3/4 or E4/4 carriers than in E3/3 carriers (95% CI -0.01 to 0.18 mmol/L) — a small effect whose confidence interval crosses zero.
link_state
linked
source
S-62 - Weggemans, Zock, Ordovas, Pedro-Botet and Katan 2001 Atherosclerosis - ApoE genotype and response of serum cholesterol to dietary fat, cholesterol and cafestol
locator
Results/Abstract, saturated-fat genotype comparison
quote
0.08 mmol/l larger in APOE3/4 or E4/4 versus E3/3 (95% CI: -0.01-0.18 mmol/l)

A genotype effect exists directionally for saturated fat (E4 carriers respond slightly more), but it is small and not statistically robust (CI includes zero) - and it is for the SFA challenge, not the dietary-cholesterol challenge.

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