Rockefeller University metabolic-ward study: 75 twelve-week diet periods testing 35% of calories as saturated or polyunsaturated fat, each at low then high dietary cholesterol, with direct measurement of cholesterol fractional absorption and mononuclear-leukocyte sterol synthesis alongside plasma lipids. In 69% of the study periods, subjects compensated for increased cholesterol intake via decreased fractional absorption and/or decreased endogenous synthesis — direct mechanistic evidence for population-level “diminishing returns” and for wide inter-individual variation in the size of that compensation. relevance_note: Directly documents the homeostatic-compensation mechanism that blunts the average LDL response to dietary cholesterol — the mechanistic basis for the “diminishing returns” pro-egg consideration.
Consolidator (step 1c) merge note: TRUE duplicate of S-25 - McNamara et al 1987 - Heterogeneity of cholesterol homeostasis in man.md — same paper (McNamara et al. 1987, J Clin Invest, DOI 10.1172/JCI113013), minted independently by slice 4 (this node) and slice 5 (S-25). Survivor is the lower id S-25; this node is retained but flagged duplicate_of.