Early Rockefeller University metabolic-ward study using isotope-kinetic methods to track total exchangeable body-cholesterol pools under controlled dietary-cholesterol manipulation. Showed that raising dietary cholesterol produces only a partial, slow rise in the body cholesterol pool because endogenous synthesis is suppressed to compensate — one of the earliest direct demonstrations of the homeostatic mechanism (rather than just its downstream plasma-LDL signature) that later studies (Keys 1965, McNamara 1987) built on. relevance_note: Early primary evidence for whole-body homeostatic buffering of dietary cholesterol, mechanistically underlying the diminishing-returns pattern in plasma LDL response.