O-4 - Daily egg intake associated with lower CVD, IHD and hemorrhagic stroke risk with dose-response in CKB
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Why this is evidence
Per-member (HC-2 order H-2, H-3, H-4, H-9, H-10, H-12):
- H-2 (protective): predicts this well - a graded inverse association at ~0.76 egg/day is close to the protective claim.
- H-3 (harmful): predicts against it; would need the whole CKB signal to be confounding.
- H-4 (neutral for IHD, inverse = reverse causation): predicts a null, but tolerates a weak apparent inverse it attributes to reverse causation; the significant dose-response trend fits it less well than H-2.
- H-9 (null in generally healthy Western adults): scope-silent on a Chinese cohort, so near-uninformative here.
- H-10 (no material effect across diverse global populations incl. low/middle-income): CKB is exactly in scope and this is the strongest disconfirming observation for H-10 of the three null variants.
- H-12 (direction varies): compatible - a protective direction in a low-baseline-intake Chinese population is what a direction-varying account predicts.