Summary: 12-week randomized, single-blind, parallel trial in 37 adults with metabolic syndrome on a moderately carbohydrate-restricted diet (25-30% energy from carbs), randomized to 3 whole eggs/day (n=20) or an equivalent yolk-free egg substitute (n=17). Whole-egg group showed greater increases in HDL-C and large HDL particles, reduced VLDL, and reduced plasma insulin/HOMA-IR (improved insulin sensitivity) versus substitute. A companion paper from the same trial/cohort (Blesso et al., J Clin Lipidol 2013;7(5):463-71, “Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome”) reports the same n=20/17 sample’s broader risk-factor panel, incl. endothelial adhesion markers VCAM-1/ICAM-1 (unchanged) — not separately minted since it is the same trial and data basis. Relevance_note: Metabolic-syndrome-defined, cardiometabolic-outcome RCT showing whole eggs improve (not worsen) insulin sensitivity and lipoprotein profile relative to substitute — PRO-egg anchor at the 4/6 slice boundary, explicitly claimed for slice 6 per the brief.