Endpoint: dual-headline — lipids (HDL-C, LDL-C, headline for slice 4/5) AND TMAO (headline for this slice); I mint it here for the TMAO finding. Flag for the consolidator to check slice 4/5 has not independently minted the same paper.
38 healthy young adults, 14-week crossover: 2-week washout then 1, 2, and 3 eggs/day for 4 weeks each. Compared to 0 eggs/day, egg intake raised HDL-C and lowered the LDL-C/HDL-C ratio (maintained across doses), and plasma choline rose dose-dependently (P<0.0001) — but fasting plasma TMAO was unchanged throughout.
relevance_note: a chronic (not acute) feeding trial showing no fasting-TMAO rise despite a real, dose-dependent choline-status increase from up to 3 eggs/day — a key skeptical/null data point for thread (iii), directly complementing Miller 2014’s acute-rise finding (chronic fasting level vs. acute postprandial spike).