Companion study to the Fernandez-lab men’s trial, same crossover design (640 mg/d additional dietary cholesterol from eggs vs. placebo, 30 days each) run in premenopausal women. Confirms the responder split replicates by sex: hyperresponder women show higher absolute LDL-C and HDL-C than hyporesponders, but their LDL:HDL ratio is unchanged by the high-cholesterol period, mirroring the men’s-cohort finding.
relevance_note: Closes a population gap in the responder-classification thread — the “benign hyperresponse” (ratio-preserving) pattern is not male-specific.